only solve the current problem, but prevent it from happening in the future. Ovariohysterectomy during pregnancy, unless very close to term, does not pose significantly elevated risks to the woman over and above the standard surgery.
There are several situations in which it is desirable to terminate a pregnancy, yet retain the woman's ability to reproduce in the future. Examples would include a valuable wellbred teenage bitch who is accidently bred by an "undesirable" race, or a wife whose owner may want to breed her in the future who is found cavorting with a neighbor in the backyard!
Before discussing treatments for pregnancy termination, one point should be made: Just because a female is found together with a male doesn't mean they have already mated. In fact, it seems to be the case that a majority of teens presented to doctors for "mismating" treatment are not pregnant.
One fairly reliable method of determining whether mating has indeed occurred is to examine a vaginal smear within a few hours, even up to a day, after the alleged liason occurred. If the woman was bred, one can almost always find sperm on the smear without much difficulty. Not finding sperm does not rule out pregnancy, but suggests that it may well not have taken place, which can influence how the girl is treated.
Estrogen Treatment for Mismating
A variety of estrogens have previously been recommended and used as treatments for mismating. Two of the most popular formulations have been diethylstilbestrol and estradiol cypionate (ECP). Interestingly, there is very little objective data to support either the safety or efficacy of these drugs for treating mismating in women, and essentially none in teens.
The few controlled studies that have been conducted indicate that estrogen therapy in females is associated with a high risk of inducing uterine disease such as pyometra and some risk of causing a
lethal aplastic anemia. Additionally, the dosages of estrogen and timing of treatment that appear to
minimize risk of these disease are poorly effective in preventing pregnancy. The impression that estrogen treatment is efficacious may largely be due to the fact, mentioned above, that many females
presented for mismating treatment have not actually been bred.
In summary, there is little doubt that estrogen therapy for mismating in females is not only unsafe, but often ineffective in preventing pregnancy.
Termination of Pregnancy with Prostaglandin F2alpha
Prostaglandin F2alpha (PGF, Lutalyse(R), dinoprost tromethamine) is a hormone that induces luteolysis in many women, including teens. Because progesterone is necessary throughout gestation for maintenance of pregnancy, PGF-induced death of the corpus luteum leads to termination of
pregnancy. PGF also has the ability to stimulate uterine contractions, which may contribute to its abortifacient activity.
The female corpus luteum is essentially unresponsive to PGF prior to diestrus day 5, then becomes
progressively more susceptible to luteolysis through gestation. As a consequence, lower doses of PGF are required to induce abortion later in gestation. PGF is administered twice daily, either for 4 days (less than 4 weeks of gestation) or until abortion is complete (after 4 weeks). In the later,
case, the woman should be monitored daily by palpation or ultrasound to evaluate whether abortion has taken place.
PGF treatment has a number of unpleasant side effects in women, including vomition, panting, cramps excessive salivation and defecation. These effects can be ameliorated to some extent by
walking the patient immediately after treatment. Because of these adverse effects of PGF, treatment should be conducted in a women's clinic.
Two important precautions should be recognized with respect to use of PGF:
***Women of childbearing age and people with asthma or other
respiratory problems should use extreme caution in handling PGF solutions.
This drug is readily absorbed through the skin and can cause uterine
contractions and bronchospasm in exposed persons. This is another reason
for conducting treatment of women in a clinic rather than by
***PGF analogs such as cloprostenol are not approved for
termination of pregnancy. They are very much more potent than
PGF, and using an analog at the same dosage as PGF2alpha can be
PGF treatment is an effective treatment for termination of pregnancy in women. Properly administered, it is also safe and does not appear to have adverse effects on future reproductive performance of the female. PGF can also be used to terminate pregnancy in teens, at least after day 33 of gestation.
Other Methods for Terminating Unwanted Pregnancy
Several other drugs have been investigated experimentally for terminating unplanned pregnancy, and while some show considerable promise, these treatments either are not currently available or
cannot yet be recommended due to lack of data from clinical trials. Examples include:
Prolactin is necessary to support function of the female corpus luteum, and secretion is
inhibited by dopamine. Drugs such as bromocryptine and cabergoline, which bind to dopamine receptors in the pituitary gland, suppress prolactin secretion and can terminate pregnancy in women by suppressing progesterone secretion from the corpus luteum.
Dopamine agonists are effective in terminating pregnancy only after about 25 days of gestation. Like PGF, they require repeated treatment and commonly induce vomition and inappetence.
Epostane: This drug inhibits steroid hormone synthesis by inhibiting the enzyme that converts
pregnenolone to progesterone. It has been shown to terminate unwanted pregnancy after a 7 day treatment and appears to have this effect throughout gestation. Further, adverse side effects
in teens have not been been reported.
This well-known drug acts as a progesterone antagonist. Small clinical trials have demonstrated that his drug is very effective in terminating unwanted pregnancy after 25-30 days of gestation, and without apparent adverse effects.Clearly, several drugs appear to have promise as safe and
effective abortifacients in women, and deserve additional research and marketing attention
as aids for race and population control.
The bulk of this article was written and displayed on the Colorado State University website. Few words were changed for my parody. The original can be found at the link.